San Francisco 49ersSF · 2026 SCHEDULE
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WEEK 1 THU SEP 10 8:35 PM ET (neutral)
AWAY @ Los Angeles RamsLAR
SCORE W 27-7
LINE -- O/U --
WX --
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WEEK 2 SUN SEP 20 4:25 PM ET
HOME vs Miami DolphinsMIA
SCORE W 35-13
LINE -- O/U --
WX --
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WEEK 3 SUN SEP 27 4:05 PM ET
HOME vs Arizona CardinalsARI
SCORE W 36-30
LINE -- O/U --
WX --
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WEEK 4 SUN OCT 4 4:25 PM ET
HOME vs Denver BroncosDEN
LINE SF -3 O/U 46.5
WX 83°F Sunny
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WEEK 5 SUN OCT 11 4:25 PM ET
AWAY @ Seattle SeahawksSEA
LINE SEA -3.5 O/U 48.5
WX --
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WEEK 6 MON OCT 19 8:15 PM ET
HOME vs Washington CommandersWSH
LINE SF -5.5 O/U 50.5
WX --
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WEEK 7 SUN OCT 25 1:00 PM ET
AWAY @ Atlanta FalconsATL
LINE SF -4.5 O/U 47.5
WX Indoors
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WEEK 8
BYE
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WEEK 9 SUN NOV 8 4:05 PM ET
HOME vs Las Vegas RaidersLV
LINE SF -8.5 O/U 46.5
WX --
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WEEK 10 SUN NOV 15 4:25 PM ET
AWAY @ Dallas CowboysDAL
LINE DAL -1.5 O/U 52.5
WX Indoors
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WEEK 11 SUN NOV 22 8:20 PM ET (neutral)
HOME vs Minnesota VikingsMIN
LINE SF -3.5 O/U 46.5
WX --
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WEEK 12 SUN NOV 29 4:25 PM ET
HOME vs Seattle SeahawksSEA
LINE SEA -1.5 O/U 46.5
WX --
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WEEK 13 SUN DEC 6 1:00 PM ET
AWAY @ New York GiantsNYG
LINE SF -3 O/U 47.5
WX --
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WEEK 14 SUN DEC 13 4:25 PM ET
HOME vs Los Angeles RamsLAR
LINE LAR -1.5 O/U 49.5
WX --
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WEEK 15 THU DEC 17 8:15 PM ET
AWAY @ Los Angeles ChargersLAC
LINE LAC -2.5 O/U 47.5
WX --
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WEEK 16 SUN DEC 27 4:25 PM ET
AWAY @ Kansas City ChiefsKC
LINE KC -3 O/U 46.5
WX --
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WEEK 17 SUN JAN 3 8:20 PM ET
HOME vs Philadelphia EaglesPHI
LINE SF -1.5 O/U 45.5
WX --
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WEEK 18 SUN JAN 10 TBD ET
AWAY @ Arizona CardinalsARI
LINE SF -8.5 O/U 44.5
WX Indoors
San Francisco 49ersSF · 2026 SCHEDULE